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LEISHMANIASIS: PROTOZOAN PARASITE INFECTING IMMUNE CELLS

Leishmania major is a species of trypanosomatid protozoa associated with the [human] disease zoonotic cutaneous leishmaniasis.

It is is an intracellular pathogen which infects the macrophages and dendritic cells of the immune system. It is able to survive by hiding inside immune cells, which engulf them but cannot destroy them.

Leishmania major is a major public health concern in Northern Africa, the Middle East, China, and Northwestern India.

IMAGES

  • L.major promastigotes [see chart] during peritoneal macrophage infection
  • L.major promastigotes during infection of primary fibroblast culture.
  • L.major amastigotes [see chart], 5 days after intracellular macrophage infection
  • Two rows: L.major amastigotes 5 days after infection of peritoneal mouse macrophages
  • Life cycle of Leishmania

Eukaryota  >  Excavata  >  Euglenozoa  >  Kinetoplastea  >
Order: Trypanosomatida  >  Genus Leishmania Ross, 1903

SOURCE: Institut Pasteur and Wikipedia

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